New York: SoHo & Nolita

I agree that the anti-seasickness medication for cruises, Bonine, is excellent and effective; but there is a budget way to buy it. The primary ingredient in Bonine is meclizine (25 mg). While a package of eight Bonine tablets costs just over $4 at a drugstore, you can buy a bottle of 100 generic meclizine (25 mg) for about the same price. This is an over-the-counter (no prescription needed) item, but you usually have to ask for it at the pharmacy counter.

Instead of bringing one of those bungee cables to hang-dry my delicates and socks, I pack a couple of mini plastic hangers--the ones that bras and panties come on when you buy them. They take up very little room in my luggage and can be thrown away at the end of the trip.

Save major bucks by going onto eBay and purchasing coupons and gift certificates that others don't want or can't use for lodging, transportation, food, and admissions. I've found great discounts for airline and Amtrak tickets; car rentals; entrance to amusement parks such as SeaWorld, Disney, or Universal Studios; as well as overnights at many hotels. For example, I bought a $30 savings coupon at SeaWorld for only $1. Simply search for your destination and then type in "coupon" or "gift certificate."

Before setting off on one of my many backpacking excursions, I head to Kinko's to rebind my guidebook. I replace the cover with a plain black or navy one. It costs about $6 and allows me to blend in much better while traveling. People see my new book as a journal, not a travel guide that labels me a tourist.

The best carry-on bag that I've found is a gardener's tote. It has lots of pockets on the outside and room inside for a medium-size purse, yet it's small enough to sit comfortably at my feet on a bus or plane.

Once we know where we're going, my girlfriends and I divide up the list of things we'd like to do on our trip and put someone in charge of each item on the list. Then that person does the legwork by finding directions and prices, making reservations (if necessary), and researching nearby places to stop for a snack or a meal. Our method means that no one person is doing all the planning.

I carry recipe cards with me to jot down interesting dishes I come across while on vacation. (I also like to use colorful postcards from the area I'm visiting and trim them to fit my recipe box.) Here's a wonderful dessert idea I brought home after spending a rainy afternoon with my husband in a London pub: Top a warm waffle with vanilla ice cream, maple syrup, and chopped pecans. It's heaven with a cup of hot tea.

I always try to work out before heading to the airport. It usually gets me tuckered out enough that I can relax and sleep on the plane. If I don't have time for pre-travel exercise, I take a brisk walk through the terminal before boarding or find a quiet spot in an empty gate for a little yoga.

On a trip to Molokai, the plane we were on was small, and luggage was crammed in every which way. At baggage claim, we noticed that someone had packed a bottle of Pine-Sol, and it had broken and leaked everywhere. Now we line our suitcases with garbage bags to protect our clothes—just in case. (It's also smart in case your bag gets left on the tarmac in a downpour.)

After looking for years for the perfect toiletries bag and being frustrated by many that were less than ideal, I finally discovered one that is just right: a soft-sided lunch box I bought at the supermarket. It has an outer zipped pocket with small compartments and slots perfect for often-used items like a toothbrush and toothpaste. There's a small removable zipper pouch inside (meant for a small ice pack) for those smaller, hard-to-find items like nail files and pill bottles. The remaining space inside is just right for larger items like shampoo and hand lotion. Other helpful features include both a small handle and shoulder strap and a waterproof, easy-to-clean interior. As an elementary school teacher, I know firsthand that it'll last: It was designed to withstand daily use by kids!

My husband and I travel to out-of-the-way towns where rural roads can be hard to navigate. We use a handheld GPS (Global Positioning System) to mark the spot where we're staying, the main highway turnoffs, and, most important, the turns to unmarked side roads. When we're back-tracking and arrive again at confusing intersections, we whip out our GPS and immediately know which route to take home.

When planning a vacation, we send away for brochures from major tour operators. They provide hotel and restaurant recommendations and sightseeing itineraries, which we then duplicate on our own. Use this trick to mimic the vacation packages of high-end tour operators for what can turn out to be a fraction of the cost.

When I called to book a hotel room in Budapest, I was offered a rate of $75 per night. After I told the concierge that I was looking for a room in the $35 range, he agreed to the lower price without much fuss. It sometimes pays to barter.

I teach a Tulane University seminar on independent European travel for first-timers. Until recently, I advocated Europe's great rail networks as the way to go. Now, with the plethora of budget airlines, I recommend a combination of the two. But it makes the planning stage—which I find almost as much fun as actually taking the trip—more involved. Thank goodness for whichbudget.com, a Web site that lists, by city, which budget airlines serve which cities. Then, to find links to all of Europe's state railway Web sites, visit railfaneurope.net. Each site generally features a travel planner and, almost invariably, an English-language option.

Flight attendants often work vampire hours and have to sleep during the day. How do we keep the sunlight from leaking into our hotel rooms? We clip a skirt hanger (or two) to the middle of the drapes to seal them together.

Before leaving on a trip, I print the names and addresses of my friends and family onto clear mailing labels. (All standard word-processing programs have preset templates for creating address labels.) Then, I take the address-label sheets with me on vacation. Since the addresses are already saved in my computer and the mailing labels are adhesive, addressing postcards has become really easy.

At a theme park, tie a brightly colored scarf to the handle of your stroller before you enter a ride. When you return, you'll be able to quickly pick out your stroller from a sea of look-alikes.

Don't settle for the first answer to your travel question. If you need flight information, it's a good idea to phone the airline more than once and ask the same question. Recently, I wanted to see if I could fly standby on an earlier flight the same day. The first time I called, I was told that the earlier flight was booked. The second time, however, an agent said there were in fact seats available, and I could certainly fly standby. In the end, not only was I able to get on the flight, but I was upgraded to first class.

Using your frequent-flier miles, you might be able to visit two cities on one ticket. For example, my wife and I always trade in our Delta miles when we visit our daughters in Dallas and San Francisco. Because we have to fly through Dallas to get to San Francisco on Delta, we can stop over in Dallas for as long as we want before continuing on to San Francisco—and we use only one frequent-flier ticket each.

For long overnight flights, pack a dry washcloth in a Ziploc bag in your carry-on. Before landing, ask the flight attendant for a cup of hot (not boiling) water. Carefully pour the water into the Ziploc bag and then wipe your face and hands with the steaming cloth. It's like a portable sauna!

Spring skiing often means a wild temperature shift from morning to afternoon. If you want the option of removing outer layers or switching to a lighter ski jacket midday, attach the lift ticket to your clothing with a split-ring key ring. You'll be able to move your ticket as the weather warms up.

When I'm planning a trip, I almost always call the hotel concierge before I arrive, and if my hotel doesn't have one, I call a hotel that does. Recently, I asked for advice on what to see since I only had four days in a new city. I told the concierge what I thought I should try to do, and she said I had too many things packed into four days. She gave me a list of hot spots to visit and places to avoid, and even recommended a florist to call on for fresh flowers. With her help, my trip was far more enjoyable than it would have been otherwise.

If your flight is canceled, don't just wait patiently in line to be booked on another flight; call the airline's 800 number. They'll answer your call faster, and you won't be waiting with other stranded passengers from that flight. (Or cover all bases by calling while in line.)

Before you go to sleep, check to see if a previous hotel guest left the alarm clock on. I've been awakened before 7 a.m. twice in the last couple of months by alarms I did not set. (Make sure the clock shows the right time, too!)

Sign up for guest programs at every hotel chain that offers one, even if you haven't stayed at that hotel before or think you may not travel enough to reap benefits from multiple stays. Some programs send coupons for discounted rooms or complimentary room upgrades just for being a member. After signing up for the Omni Hotels Select Guest program, I received a coupon that I was able to redeem for a room in Chicago for $80 per night.

If the porters haven't delivered your luggage to your door by the first night of the cruise, check what our experts call the "naughty room." Security will store any bags containing contraband (like candles, alcohol, or coffeemakers) in this centralized location until you come claim it. You'll be able to pick up your bag on the first night, but banned items will not be returned until the end of the trip.

If your vacation spot is a major port of call for cruise ships, plan excursions for the days that the ships aren't docked. Tours will be less crowded, and you'll get to see and do a lot more.

During the hot months of summer, I plan to travel with a very small spray bottle. I'll fill it with water and use it as a mister to keep cool. I got this idea when we stayed at the Noga Hilton in Cannes. On the dresser was a pink aerosol can full of Evian water. I took it with us sightseeing and, wow, it was so refreshing to spritz water on our faces.

It's unnecessary to make a packing list for each trip. Instead, draw up a master list with everything you might need on any given trip--from ski goggles to snorkels, slippers to saline solution. Save it on your computer. Before you start packing, cross out anything you don't need for that particular trip.

When on vacation, I split my cash into envelopes, one per day, so I can keep track of how much I'm spending. If I need to dig into the next day's cash, I'll know that I've overdone it, and if I want to stay on budget, I'll have to cut back the next day. Any money left at the end of the day goes into a separate envelope. I've actually come home with money this way!