Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwest corner. It is situated along the Tennessee River and is home to the University of North Alabama, the oldest college in the state. According to the 2010 census, the city's population was 39,319. Florence is the largest and principal city of the Florence-Muscle Shoals Metropolitan Statistical Area commonly known as "The Shoals" (which also includes the cities of Muscle Shoals, Sheffield, and Tuscumbia in Colbert County). Florence is considered northwestern Alabama's primary economic hub. Annual tourism events include the W. C. Handy Music Festival in the summer and the Renaissance Faire in the fall. Landmarks in Florence include the Rosenbaum House, the only Frank Lloyd Wright-designed home located in Alabama, and the Florence Indian Mound and Museum. The type of municipal government is mayor-council.

Tuscumbia is a city in and the county seat of Colbert County, Alabama, United States. As of the 2010 census, the population was 8,423. The city is part of The Shoals metropolitan area. Tuscumbia was the hometown of Helen Keller (Ivy Green) and much of the city is listed on the National Register of Historic Places as the Tuscumbia Historic District. The city serves as the location for the Alabama Music Hall of Fame.

Athens is a city in and the county seat of Limestone County, in the U.S. state of Alabama; it is included in the Huntsville-Decatur-Albertville, AL Combined Statistical Area. As of the 2010 census, the population of the city is 21,897.

Decatur (dɪˈkeɪtə(r)) is a city in Morgan and Limestone counties in the U.S. state of Alabama. The city, nicknamed "The River City", is located in Northern Alabama on the banks of Wheeler Lake, along the Tennessee River. It is the largest city and county seat of Morgan County. The population in 2010 was 55,683.Decatur is also the core city of the two-county large Decatur, Alabama metropolitan area which had an estimated population of 153,374 in 2013. Combined with the Huntsville Metropolitan Area, the two create the Huntsville-Decatur Combined Statistical Area, of which Decatur is the second-largest city. Like many southern cities in the early 19th century, Decatur's early success was based upon its location along a river. Railroad routes and boating traffic pushed the city to the front of North Alabama's economic atmosphere. The city rapidly grew into a large economic center within the Tennessee Valley and was a hub for travelers and cargo between Nashville and Mobile, as well as Chattanooga and New Orleans. Throughout the 20th century, the city experienced steady growth, but was eclipsed as the regional economic center by the fast-growing Huntsville during the space race. The city now finds its economy heavily based on manufacturing, mining, cargo transit, chemical, and high-tech companies such as Vulcan Materials, Daikin, Toray, and United Launch Alliance.