The City and Borough of Wrangell (Tlingit: Ḵaachx̱aana.áakʼw, Russian: Врангель) is a borough in Alaska, United States. As of the 2010 census the population was 2,369, up from 2,308 in 2000. Incorporated as a Unified Home Rule Borough on May 30, 2008, Wrangell was previously a city in the Wrangell-Petersburg Census Area (afterwards renamed the Petersburg Census Area (the Petersburg Borough was formed from part of this census area)). Its Tlingit name is Ḵaachx̱aana.áakʼw ("Ḵaachx̱ans Little Lake" with áa-kʼw 'lake-diminutive'). The Tlingit people living in the Wrangell area, who were there centuries before Europeans, call themselves the Shtaxʼhéen Ḵwáan after the nearby Stikine River. Alternately they use the autonym Shxʼát Ḵwáan, where the meaning of shxʼát is unknown. The central (urban) part of Wrangell is located at 56°28′15″N 132°22′36″W, in the northwest corner of Wrangell Island, whereas the borough now encompasses the entire eastern half of the former Wrangell-Petersburg Census Area, in addition to the area around Meyers Chuck, which was formerly in the Prince of Wales-Outer Ketchikan Census Area. It also includes Thoms Place, a former census-designated place on Wrangell Island.

Ketchikan ( KETCH-ih-kan; Tlingit: Kichx̱áan) is a city in and the borough seat of the Ketchikan Gateway Borough of Alaska. It is the state's southeasternmost major settlement. Downtown Ketchikan is a National Historic District. With a population at the 2010 census of 8,050, it is the fifth-most populous city in the state, and tenth-most populous community when census-designated places are included. The surrounding borough, encompassing suburbs both north and south of the city along the Tongass Highway (most of which are commonly regarded as a part of Ketchikan, albeit not a part of the city itself), plus small rural settlements accessible mostly by water, registered a population of 13,477 in that same census. US Census results put the 2019 population at 13,901 people. Incorporated on August 25, 1900, Ketchikan is the earliest extant incorporated city in Alaska, because consolidation or unification elsewhere in Alaska resulted in the dissolution of those communities' city governments. Ketchikan is located on Revillagigedo Island, so named in 1793 by Captain George Vancouver. Ketchikan is named after Ketchikan Creek, which flows through the town, emptying into the Tongass Narrows a short distance southeast of its downtown. "Ketchikan" comes from the Tlingit name for the creek, Kitschk-hin, the meaning of which is unclear. It may mean "the river belonging to Kitschk"; other accounts claim it means "Thundering Wings of an Eagle". In modern Tlingit, this name is Kichx̱áan.

Sitka (Tlingit: Sheetʼká, Russian: Ситка) is a unified city-borough in the southeast portion of the U.S. state of Alaska. It was formerly (between 1799 and 1867) Novo-Arkhangelsk (or New Archangel) under Russian rule (Russian: Ново-Архангельск or Новоaрхангельск, t Novoarkhangelsk). The city is situated on the west side of Baranof Island and the south half of Chichagof Island in the Alexander Archipelago of the Pacific Ocean (part of the Alaska Panhandle). As of the 2010 census, Sitka had a population of 8,881.With a consolidated land area of 2,870.3 square miles (7,434 square kilometers) and total area (including water) of 4,811.4 square miles (12,461 km2), Sitka is the largest city-borough by total area in the U.S.

Juneau ( JOO-noh; Tlingit: Dzánti K'ihéeni [ˈtsʌ́ntʰɪ̀ kʼɪ̀ˈhíːnɪ̀]) is the capital city of the state of Alaska. Located in the Gastineau Channel and the Alaskan panhandle, it is a unified municipality and the second-largest city in the United States of America by area. Juneau was named the capital of Alaska in 1906, when the government of what was then the District of Alaska was moved from Sitka as dictated by the U.S. Congress in 1900. The municipality unified on July 1, 1970, when the city of Juneau merged with the city of Douglas and the surrounding Greater Juneau Borough to form the current municipality, which is larger by area than both Rhode Island and Delaware. Downtown Juneau (58°18′00″N 134°24′58″W) is nestled at the base of Mount Juneau and across the channel from Douglas Island. As of the 2010 census, the City and Borough had a population of 31,276. In 2019, the population estimate from the United States Census Bureau was 31,974, making it the second-most populous city in Alaska after Anchorage. Juneau experiences a daily influx of roughly 6,000 people from visiting cruise ships between the months of May and September. The city is named after a gold prospector from Quebec, Joe Juneau, though the place was for a time called Rockwell and then Harrisburg (after Juneau's co-prospector, Richard Harris). The Tlingit name of the town is Dzántik'i Héeni ("Base of the Flounder's River," dzánti 'flounder,' –kʼi 'base,' héen 'river'), and Auke Bay just north of Juneau proper is called Áak'w ("Little lake," áa 'lake,' -kʼ 'diminutive') in Tlingit. The Taku River, just south of Juneau, was named after the cold t'aakh wind, which occasionally blows down from the mountains. Juneau is unique among the 49 U.S. capitals on mainland North America in that there are no roads connecting the city to the rest of the state nor North America. Honolulu, Hawaii, is the only other state capital not connected by road to the rest of North America. The absence of a road network is due to the extremely rugged terrain surrounding the city. This in turn makes Juneau a de facto island city in terms of transportation, since all goods coming in and out must go by plane or boat, in spite of the city's being on the Alaskan mainland. Downtown Juneau sits at sea level, with tides averaging 16 feet (5 m), below steep mountains about 3,500 to 4,000 feet (1,100 to 1,200 m) high. Atop these mountains is the Juneau Icefield, a large ice mass from which about 30 glaciers flow; two of these, the Mendenhall Glacier and the Lemon Creek Glacier, are visible from the local road system. The Mendenhall glacier has been gradually retreating; its front face is declining in width and height. The Alaska State Capitol in downtown Juneau was built as the Federal and Territorial Building in 1931. Prior to statehood, it housed federal government offices, the federal courthouse and a post office. It also housed the territorial legislature and many other territorial offices, including that of the governor. Today, Juneau remains the home of the state legislature and the offices of the governor and lieutenant governor. Some other executive branch offices have moved elsewhere in the state.