Lexington is the second-largest city in Kentucky and the county seat of Fayette County. By population, it is the 60th-largest city in the United States, and by land area, is the country's 28th-largest city. Known as the "Horse Capital of the World", it is the heart of the state's Bluegrass region. Notable locations in the city include the Kentucky Horse Park, The Red Mile and Keeneland race courses, Rupp Arena, Transylvania University, the University of Kentucky, and Bluegrass Community and Technical College. Lexington ranks 10th among US cities in college education rate, with 39.5% of residents having at least a bachelor's degree and 92.2% of households having at least one personal computer.In the 2019 U.S. Census Estimate, the city's population was 323,152, anchoring a metropolitan area of 517,056 people and a combined statistical area of 745,033 people. Lexington is consolidated entirely within Fayette County, and vice versa. It has a nonpartisan mayor-council form of government, with 12 council districts and three members elected at large, with the highest vote-getter designated vice mayor.

Kentucky (kən-TUK-ee, UK: ken-), officially the Commonwealth of Kentucky, is a state in the Southeastern region of the United States, bordered by Illinois, Indiana, and Ohio to the north; West Virginia and Virginia to the east; Tennessee to the south; and Missouri to the west.

Harrodsburg is a home rule-class city in Mercer County, Kentucky, United States. It is the seat of its county. The population was 8,340 at the 2010 census. Although Harrodsburg was formally established by the House of Burgesses after Boonesborough and was not incorporated by the Kentucky legislature until 1836, it is usually considered the oldest city in Kentucky and has been honored as the oldest permanent American settlement west of the Appalachians.

Danville is a home rule-class city in Boyle County, Kentucky, United States. It is the seat of its county. The population was 16,218 at the 2010 Census. Danville is the principal city of the Danville Micropolitan Statistical Area, which includes all of Boyle and Lincoln counties. In 2001, Danville received a Great American Main Street Award from the National Trust for Historic Preservation. In 2011, Money magazine placed Danville as the fourth-best place to retire in the United States. Centre College in Danville was selected to host U.S. Vice-Presidential debates in 2000 and 2012.