Thomasville is a city in Davidson County, North Carolina, United States. The population was 26,757 at the 2010 census. The city was once notable for its furniture industry, as were its neighbors High Point and Lexington. This Piedmont Triad community was established in 1852 and hosts the state's oldest festival, "Everybody's Day". Built around the local railway system, Thomasville is home to the oldest railroad depot in the state, just a few hundred feet from the city's most notable landmark, "The Big Chair".

Greensboro ( (listen); formerly Greensborough) is a city in and the county seat of Guilford County, North Carolina, United States. It is the third-most populous city in North Carolina, the 68th-most populous city in the United States, and the largest city in the Piedmont Triad metropolitan region. At the 2020 United States census, its population was 299,035. Three major interstate highways (Interstate 40, Interstate 85, and Interstate 73) in the Piedmont region of central North Carolina were built to intersect at this city. In 1808, Greensborough (the spelling before 1895) was planned around a central courthouse square to succeed Guilford Court House as the county seat. The county courts were thus placed closer to the county's geographical center, a location more easily reached at the time by the majority of the county's citizens, who traveled by horse or on foot. In 2003, the previous Greensboro–Winston-Salem–High Point metropolitan statistical area was redefined by the U.S. Office of Management and Budget. The region was separated into the Greensboro–High Point metropolitan area and the Winston-Salem metropolitan area. The 2010 population of the Greensboro–High Point metropolis was 723,801. The combined statistical area (CSA) of Greensboro–Winston-Salem–High Point, commonly called the Piedmont Triad, had a population of 1,599,477. Among Greensboro's many notable attractions, some of the most popular are the Greensboro Science Center, the International Civil Rights Museum, the Weatherspoon Art Museum, the Greensboro Symphony, the Greensboro Ballet, Triad Stage, the Wyndham Golf Championship, and the headquarters of the Atlantic Coast Conference, the Greensboro Coliseum Complex, which hosts various sporting events, concerts, and other events. Sports teams in Greensboro include the Greensboro Grasshoppers of the South Atlantic Baseball League, the Carolina Dynamo of USL League Two, the Greensboro Swarm of the NBA G League, and the Greensboro Roller Derby. Annual events include the North Carolina Folk Festival, First Fridays in Downtown Greensboro, Fun Fourth of July Festival, North Carolina Comedy Festival and Winter Wonderlights. From 2015 to 2017 Greensboro hosted the National Folk Festival.

Lexington is the county seat of Davidson County, North Carolina, United States. As of the 2010 census, the city had a population of 18,931. It is located in central North Carolina, 20 miles (32 km) south of Winston-Salem. Major highways include I-85, I-85B, U.S. Route 29, U.S. Route 70, U.S. Route 52 (soon to be I-285) and U.S. Route 64. Lexington is part of the Piedmont Triad region of the state. Lexington, Thomasville, and the rural areas surrounding them are slowly developing as residential bedroom communities for nearby cities such as Winston-Salem, Greensboro, High Point and, to a lesser extent, Charlotte and its northeastern suburbs.

Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. In 2020, the population was 249,545 making it the second largest municipality in the Piedmont Triad region, the fifth most populous city in North Carolina, the third largest urban area in North Carolina, and the 89th most populous city in the United States. With a metropolitan population of 679,948 it is the fourth largest metropolitan area in North Carolina. Winston-Salem is home to the tallest office building in the region, 100 North Main Street, formerly known as the Wachovia Building and now known locally as the Wells Fargo Center. In 2003, the Greensboro-Winston-Salem-High Point metropolitan statistical area was redefined by the U.S. Office of Management and Budget. The region was separated into two major metropolitan areas of Winston-Salem and Greensboro-High Point. The population of the Winston-Salem metropolitan area in 2020 was 679,948. The metro area covers over 2,000 square miles and spans over the five counties of Forsyth, Davidson, Stokes, Davie, and Yadkin. Winston-Salem is called the "Twin City" for its dual heritage. "Camel City" is a reference to the city's historic involvement in the tobacco industry related to locally based R. J. Reynolds Tobacco Company's Camel cigarettes. Many natives of the city and North Carolina refer to the city as "Winston" in informal speech. Winston-Salem is also home to six colleges and institutions, most notably Wake Forest University, Winston-Salem State University, and the University of North Carolina School of the Arts which ranks as one the best film schools in America. In 2021, the city ranked No. 46 out of 150 cities on the "Best Places to Live" list from U.S. News & World Report. In April 2021, a study from Lendingtree's Magnify Money blog ranked Winston-Salem as the second-best tech market for women.