Central Oklahoma is the geographical name for the central region of the U.S. state of Oklahoma. It is also known by the Oklahoma Department of Tourism designation, Frontier Country, defined as the twelve-county region including Canadian, Grady, Logan, Oklahoma, Cleveland, McClain, Payne, Lincoln, Pottawatomie, Seminole, Okfuskee, and Hughes counties.Central Oklahoma is dominated by the largest urban area in the state, the Greater Oklahoma City area. Oklahoma City is the political, economic, tourism, commercial, industrial, financial, and geographical hub of the state, as well as being its primary cultural center. The only Central Oklahoma city which is not officially considered a suburb of Oklahoma City is Stillwater, Oklahoma.

Edmond is a city in Oklahoma County, Oklahoma, United States, and a part of the Oklahoma City metropolitan area in the central part of the state. The population is approximately 94,054, according to estimates from ESRI. Edmond is the fifth largest city in the state of Oklahoma. The city borders the northern boundary of Oklahoma City. Public transportation is provided by Citylink Edmond bus service.

Stillwater is a city in, and the county seat of, Payne County, Oklahoma, United States. It is located in north-central Oklahoma at the intersection of U.S. Route 177 and State Highway 51. As of the 2010 census, the city population was 45,688, making it the tenth-largest city in Oklahoma. The Stillwater Micropolitan Statistical Area had a population of 78,399 according to the 2012 census estimate. Stillwater was part of the first Oklahoma Land Run held on April 22, 1889 when the Unassigned Lands were opened for settlement and became the core of the new Oklahoma Territory. The city charter was adopted on August 24, 1889, and operates under a council-manager government system. Stillwater has a diverse economy with a foundation in aerospace, agribusiness, biotechnology, optoelectronics, printing and publishing, and software and standard manufacturing. Stillwater is home to the main campus of Oklahoma State University (the city's largest employer) as well as Northern Oklahoma College – Stillwater, Meridian Technology Center, and the Oklahoma Department of Career and Technology Education. The city is home to the National Wrestling Hall of Fame and Museum.

Oklahoma City ( (listen)), officially the City of Oklahoma City, and often shortened to OKC, is the capital and largest city of the U.S. state of Oklahoma. The county seat of Oklahoma County, it ranks 22nd among United States cities in population, and is the 11th largest city in the Southern United States. The population grew following the 2010 census and reached 681,054 in the 2020 census. The Oklahoma City metropolitan area had a population of 1,396,445, and the Oklahoma City–Shawnee Combined Statistical Area had a population of 1,469,124, making it Oklahoma's largest municipality and metropolitan area by population. Oklahoma City's city limits extend somewhat into Canadian, Cleveland, and Pottawatomie counties, though much of those areas outside the core Oklahoma County area are suburban tracts or protected rural zones (watershed). The city is the eighth-largest in the United States by area including consolidated city-counties; it is the second-largest, after Houston, not including consolidated cities. The city is also the second largest by area among state capital cities in the United States, after Juneau, Alaska. Oklahoma City has one of the world's largest livestock markets. Oil, natural gas, petroleum products and related industries are its economy's largest sector. The city is in the middle of an active oil field and oil derricks dot the capitol grounds. The federal government employs a large number of workers at Tinker Air Force Base and the United States Department of Transportation's Mike Monroney Aeronautical Center (which house offices of the Federal Aviation Administration and the Transportation Department's Enterprise Service Center, respectively). Oklahoma City is on the I-35 Corridor, one of the primary travel corridors south into neighboring Texas and Mexico and north towards Wichita and Kansas City. Located in the state's Frontier Country region, the city's northeast section lies in an ecological region known as the Cross Timbers. The city was founded during the Land Run of 1889 and grew to a population of over 10,000 within hours of its founding. It was the scene of the April 19, 1995, bombing of the Alfred P. Murrah Federal Building, in which 168 people died, the deadliest terror attack in U.S. history until the attacks of September 11, 2001, and the deadliest act of domestic terrorism in U.S. history. Since weather records have been kept, Oklahoma City has been struck by 13 violent tornadoes, 11 of which were rated F4 or EF4 on the Fujita and Enhanced Fujita scales, and two F5 or EF5.