The Upstate is the region in the westernmost part of South Carolina, United States, also known as the Upcountry, which is the historical term. Although loosely defined among locals, the general definition includes the ten counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville–Spartanburg–Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget in 2015. In 2018, the OMB redefined the CSA such that it no longer included Abbeville County. That definition remains as of 2020. The region's population was 1,347,112 as of 2016. Situated between Atlanta and Charlotte, the Upstate is the geographical center of the Charlanta mega-region. After BMW's initial investment, foreign companies, including others from Germany, have a substantial presence in the Upstate; several large corporations have established regional, national, or continental headquarters in the area. Greenville is the largest city in the region with a population of 72,227 and an urban-area population of 400,492, and it is the base of most commercial activity. Spartanburg and Anderson are next in population.

Greenville (; locally ) is a city in and the seat of Greenville County, South Carolina, United States. With an estimated population of 70,635 as of 2019, it is the sixth-largest city in the state. Greenville is located approximately halfway between Atlanta, Georgia, and Charlotte, North Carolina, along Interstate 85, and its metropolitan area also includes Interstates 185 and 385. Greenville was the fourth fastest-growing city in the United States between 2015 and 2016, according to the U.S. Census Bureau.The population of the surrounding area was 400,492 as of 2010, making it the third-largest urban area in South Carolina as well as the fastest growing. Greenville is the largest city in the Greenville-Anderson-Mauldin Metropolitan Statistical Area. The MSA had a population of 920,477 in 2019, making it the largest in South Carolina and the third largest in the Carolinas. Greenville is the largest city in the Greenville-Spartanburg-Anderson Combined Statistical Area, a 10-county region of northwestern South Carolina known as "The Upstate". According to United States Census Bureau, the CSA had a population of 1,475,235 as of 2019, making it the largest CSA in the state.

Travelers Rest is a city in Greenville County, South Carolina, United States. The population was 4,576 at the 2010 census, up from 4,099 in 2000. The population was an estimated 5,253 in 2018. It is part of the Greenville–Mauldin–Easley Metropolitan Statistical Area. Travelers Rest is located between the Blue Ridge Mountains and Greenville, the primary city of the Upstate region of South Carolina. The campus of Furman University is located just south of the city limits of Travelers Rest, but the university retains a Greenville address based on its ZIP code.

Ninety-Six District (not "96th") is a former judicial district in the U.S. state of South Carolina. It existed as a district from 29 July 1769 to 31 December 1799. The court house and jail for Ninety-Six District were in Ninety Six, South Carolina.