Mitchell is a city in, and the county seat of, Davison County, South Dakota, United States. The population was 15,254 at the 2010 census making it the sixth most populous city in South Dakota. Mitchell is the principal city of the Mitchell Micropolitan Statistical Area, which includes all of Davison and Hanson counties.

Watertown is a city in and the county seat of Codington County, South Dakota, United States. Watertown is home to the Redlin Art Center which houses many of the original art works produced by Terry Redlin, one of America's most popular wildlife artists. Watertown is located between Pelican Lake and Lake Kampeska, from which Redlin derived inspiration for his artwork. The population was 21,482 at the 2010 census, making Watertown the fifth largest city in South Dakota. It is also the principal city of the Watertown Micropolitan Statistical Area, which includes all of Codington and Hamlin counties. Watertown also is home to the Bramble Park Zoo. Watertown's residential real estate is considered the most expensive in South Dakota for cities of its size; the median price for a home in Watertown is approximately $200,000.

Lake Agassiz was a large glacial lake in central North America. Fed by glacial meltwater at the end of the last glacial period, its area was larger than all of the modern Great Lakes combined, although its mean depth was not as great as that of many major lakes today. First postulated in 1823 by William H. Keating, it was named by Warren Upham in 1879 after Louis Agassiz, when Upham recognized that the lake was formed by glacial action.

Chamberlain (Lakota: makȟáthipi; "earth dwelling") is a city in Brule County, South Dakota, United States. It is located on the eastern bank of the Missouri River, at the dammed section of the Lake Francis Case, close to where it is crossed by Interstate 90. The population of Chamberlain was 2,387 at the 2010 census. It is the county seat of Brule County.Chamberlain is home to the South Dakota Hall of Fame. It is the site of St. Joseph's Indian School, a Native American residential school established in 1927 and operated by the Catholic order Priests of the Sacred Heart. A 50-foot (15 m) sculpture of a Native American woman, entitled Dignity, was installed on a bluff overlooking the Missouri River outside the city.