Midland is a city in and the county seat of Midland County, Texas, United States, on western Texas's Southern Plains. A small part of Midland is in Martin County. At the 2010 census, Midland's population was 111,147, and a 2019 estimate put it at 176,832, making it Texas's 24th-most populous city. It is the principal city of the Midland, Texas metropolitan statistical area, which includes all of Midland County, the population of which grew 4.6% between July 1, 2011, and July 1, 2012, to 151,662, according to the U.S. Census Bureau. The metropolitan area is part of the larger Midland–Odessa combined statistical area, which had an estimated population of 295,987 on July 1, 2012. People in Midland are called Midlanders. Midland was founded as the midway point between Fort Worth and El Paso on the Texas and Pacific Railroad in 1881. It is the hometown of former First Lady Laura Bush, and the onetime home of former Presidents George H. W. Bush and George W. Bush, and former First Lady Barbara Bush.

Odessa is a city in and the county seat of Ector County, Texas, United States. It is located primarily in Ector County, although a small section of the city extends into Midland County. Odessa's population was 114,428 at the 2020 census, making it the 28th-most populous city in Texas;It is the principal city of the Odessa metropolitan statistical area, which includes all of Ector County. The metropolitan area is also a component of the larger Midland–Odessa combined statistical area, which had a 2010 census population of 278,801; a recent report from the United States Census Bureau estimates that the combined population as of July 2015 is 320,513. In 2014, Forbes magazine ranked Odessa as the third-fastest-growing small city in the United States. In 1948 Odessa was also the home of First Lady Barbara Bush, and the onetime home of former Presidents George H. W. Bush and George W. Bush. Former President George H.W. Bush has been quoted as saying "At Odessa we became Texans and proud of it."

Sweetwater is a municipality in and the seat of Nolan County, Texas, United States. It is 236 miles southeast of Amarillo and 181 miles west of Fort Worth. Its population was 10,906 at the 2010 census.

San Angelo is a city in and the county seat of Tom Green County, Texas, United States. Its location is in the Concho Valley, a region of West Texas between the Permian Basin to the northwest, Chihuahuan Desert to the southwest, Osage Plains to the northeast, and Central Texas to the southeast. According to a 2019 Census estimate, San Angelo has a total population of 101,004. It is the principal city and center of the San Angelo metropolitan area, which has a population of 118,182.San Angelo is home to Angelo State University, historic Fort Concho, and Goodfellow Air Force Base. Common nicknames of the city include Angelo, the Concho City, the Pearl of the Conchos, and the Oasis of West Texas.