Roanoke () is an independent city in the U.S. commonwealth of Virginia. As of the 2020 census, the population was 100,011, making it the largest city in Virginia west of Richmond. It is located in the Roanoke Valley of the Roanoke Region of Virginia.Roanoke is the largest municipality in Southwest Virginia, and is the principal municipality of the Roanoke Metropolitan Statistical Area (MSA), which had a 2020 population of 315,251. It is composed of the independent cities of Roanoke and Salem, and Botetourt, Craig, Franklin, and Roanoke counties. Bisected by the Roanoke River, Roanoke is the commercial and cultural hub of much of Southwest Virginia and portions of Southern West Virginia.

Blacksburg is an incorporated town in Montgomery County, Virginia, United States, with a population of 42,620 at the 2010 census. Blacksburg, as well as the surrounding county, is dominated economically and demographically by the presence of Virginia Tech (Virginia Polytechnic Institute and State University).Blacksburg, Christiansburg, and the city of Radford are the three principal jurisdictions of the Blacksburg-Christiansburg Metropolitan Statistical Area, which encompasses those jurisdictions and all of Montgomery, Pulaski, and Giles counties for statistical purposes. The MSA has an estimated population of 181,863 and is currently one of the faster-growing MSAs in Virginia. In 2011, BusinessWeek named Blacksburg as the "Best Place in the U.S. to Raise Kids". Also in 2011, readers of Southern Living named Blacksburg the "Best College Town in the South". Its public transportation system, Blacksburg Transit, which also connects to the neighboring town of Christiansburg, has repeatedly been recognized for the quality of its service. Blacksburg High School, which in 2013 opened a new building, is often ranked among the top schools of the nation for its academics. Its soccer, track, and cross-country teams are also among the top in the state. Blacksburg was the scene of the Virginia Tech shootings on April 16, 2007, when 32 people were killed and 17 wounded by a lone gunman. At the time, it was the deadliest shooting carried out by a single gunman in U.S. history, and generated considerable media coverage and discussion.

Montgomery County is a county located in the Valley and Ridge area of the U.S. state of Virginia. As population in the area increased, Montgomery County was formed in 1777 from Fincastle County, which in turn had been taken from Botetourt County. As of the 2020 census, the population was 99,721. Its county seat is Christiansburg.Montgomery County is part of the Blacksburg–Christiansburg, VA Metropolitan Statistical Area. It is dominated economically by the presence of Virginia Tech, Virginia's second largest public university, which is the county's largest employer.

This is a list of hospitals in the United States that are verified as trauma centers by the American College of Surgeons.