Smyth County is a county located in the U.S. state of Virginia. As of the 2020 census, the population was 29,800. Its county seat is Marion.

Bluefield is a city in Mercer County, West Virginia, United States. The population was 10,447 at the 2010 census. It is the core city of the Bluefield WV-VA micropolitan area, which has a population of 107,342.

Wytheville () is a town in, and the county seat of, Wythe County, in southwestern Virginia, United States. It is named after George Wythe, a signer of the United States Declaration of Independence, and mentor to Thomas Jefferson. Wytheville's population was 8,211 at the 2010 census. Interstate Highways 77 and 81 were constructed to intersect at the town, long a crossroads for travelers. During the American Civil War, Wytheville had a strategic importance. It was attacked in 1863 (Toland's Raid) and 1865 (Stoneman's 1865 Raid). The town is the birthplace of Edith Bolling Wilson, second wife of President Woodrow Wilson.

Russell County () is a county located in the Commonwealth of Virginia. As of the 2010 census, the population was 28,897. Its county seat is Lebanon.