Appleton is a city in Outagamie, Calumet, and Winnebago counties in the U.S. state of Wisconsin. One of the Fox Cities, it is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. Appleton is the county seat of Outagamie County. As of the 2020 Census it had a population of 75,644, making it the sixth largest city in Wisconsin. Appleton is a part of the Fox Cities metropolitan area, the third largest in the state behind Milwaukee and Madison. Appleton serves as the heart of the Fox River Valley and is home to Lawrence University, the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton. It also hosts regional events such as Octoberfest and the Mile of Music.

The Fox Cities of Northeastern Wisconsin are the cities, towns and villages along the Fox River as it flows from Lake Winnebago northward into Green Bay. The Fox Cities communities, as defined by its Chamber of Commerce and Convention and Visitors Bureau, include: The cities of Appleton (pop. 74,526), Kaukauna (16,246), Menasha (17,771), Neenah (26,062), and Oshkosh (67,004). The villages of Combined Locks (pop. 3,588), Fox Crossing (19,029), Harrison (11,532), Hortonville (2,767), Kimberly (6,803), Little Chute (11,564), and Sherwood (2,985). The towns of Buchanan (pop. 6,755), Clayton (3,951), Freedom (5,842), Grand Chute (20,919), Greenville (10,309), Kaukauna (1,238), Neenah (3,237), Vandenbroek (1,474).Major points of interest include the Fox Cities Exhibition Center, Community First Champion Center, Fox Cities Performing Arts Center, High Cliff State Park, and Neuroscience Group Field at Fox Cities Stadium. The Fox River Mall is the largest shopping mall in the state at 1.2 million square feet.Area post-secondary schools include Fox Valley Technical College, Lawrence University, and the University of Wisconsin-Oshkosh, Fox Cities Campus. Bus transit for the area is provided by Valley Transit and commercial airline service is provided by Appleton International Airport. Major highway routes in the area include: Interstate 41/U.S. Route 41, which connects the Fox Cities with Green Bay and Milwaukee; Wisconsin Highway 441, known locally as the Tri-County Expressway, which is an auxiliary highway of Interstate 41 that serves as a beltway around Appleton; and U.S. Route 10 which travels east-west, connecting the Fox Cities with Stevens Point/Waupaca and Manitowoc. Television and radio stations in the area, usually originating out of Green Bay, utilize the term "Green Bay/Fox Cities" in their station identifications to encompass both major population centers in the region.

Oshkosh is a city in Winnebago County, Wisconsin, of which it is the county seat. The city had an estimated population of 67,004 in 2019, making it the ninth-largest city in Wisconsin. It is also adjacent to the Town of Oshkosh.

Elkhart Lake may refer to: Elkhart Lake, Wisconsin, USA; a village Elkhart Lake, a lake within the bounds of Elkhart Lake, Wisconsin, USA Elkhart Lake-Glenbeulah High School, Elkhart Lake, Sheboygan County, Wisconsin, USA Road America (RA), Sheboygan County, Wisconsin, USA; a motorsports racetrack also known as Elkhart Lake Elkhart Lake (microprocessor), a 10-nm CPU microarchitecture from Intel