New carry-ons have slots to a) keep your laptop safe, and b) allow you to slip your computer in and out at places such as airport security.
Briggs & Riley The Executive Traveler bag comes with a removable laptop sleeve. The bag has enough room for a long weekend. briggs-riley.com, $429
Brenthaven The Duo 15 Wheeled Case has plenty of pockets (including a padded laptop slot). But it's best for those who pack very light. brenthaven.com, $200
Solo The Rolling Laptop Overnighter has as much packing space as the Brenthaven bag above, but in a smaller overall package. solocases.com, $180
Shop Around! We're listing manufacturers' suggested prices, but vendors like ebags.com often have luggage for a lot less.