Blacksburg is an incorporated town in Montgomery County, Virginia, United States, with a population of 42,620 at the 2010 census. Blacksburg, as well as the surrounding county, is dominated economically and demographically by the presence of Virginia Tech (Virginia Polytechnic Institute and State University).Blacksburg, Christiansburg, and the city of Radford are the three principal jurisdictions of the Blacksburg-Christiansburg Metropolitan Statistical Area, which encompasses those jurisdictions and all of Montgomery, Pulaski, and Giles counties for statistical purposes. The MSA has an estimated population of 181,863 and is currently one of the faster-growing MSAs in Virginia. In 2011, BusinessWeek named Blacksburg as the "Best Place in the U.S. to Raise Kids". Also in 2011, readers of Southern Living named Blacksburg the "Best College Town in the South". Its public transportation system, Blacksburg Transit, which also connects to the neighboring town of Christiansburg, has repeatedly been recognized for the quality of its service. Blacksburg High School, which in 2013 opened a new building, is often ranked among the top schools of the nation for its academics. Its soccer, track, and cross-country teams are also among the top in the state. Blacksburg was the scene of the Virginia Tech shootings on April 16, 2007, when 32 people were killed and 17 wounded by a lone gunman. At the time, it was the deadliest shooting carried out by a single gunman in U.S. history, and generated considerable media coverage and discussion.

This is a list of hospitals in the United States that are verified as trauma centers by the American College of Surgeons.

Radford (formerly Lovely Mount, Central City, English Ferry and Ingle's Ferry) is an independent city in the U.S. state of Virginia. As of 2010, the population was 16,408 by the United States Census Bureau. For statistical purposes, the Bureau of Economic Analysis combines the city of Radford with neighboring Montgomery County. Radford is included in the Blacksburg–Christiansburg metropolitan area. Radford is the home of Radford University. The Radford Arsenal is nearby in Pulaski and Montgomery counties. Radford City has four schools: McHarg Elementary, Belle Heth Elementary, Dalton Intermediate, and Radford High School.

Giles County is a county located in the U.S. state of Virginia on the West Virginia state line. As of the 2010 census, the population was 17,286. Its county seat is Pearisburg.Giles County is included in the Blacksburg-Christiansburg, VA Metropolitan Statistical Area. Giles County is the location of Mountain Lake, one of only two natural fresh water lakes in Virginia. The lake drains into Little Stony Creek, which passes over a waterfall known as The Cascades before reaching the New River.