Cleveland is a city in Bolivar County, Mississippi, United States. The population was 10,611 as of the 2020 United States Census. Cleveland has a large commercial economy, with numerous restaurants, stores, and services along U.S. 61. Cleveland is one of the two county seats of Bolivar County (the other being Rosedale).

Greenwood is a city in and the county seat of Leflore County, Mississippi, United States, located at the eastern edge of the Mississippi Delta region, approximately 96 miles north of the state capital, Jackson, and 130 miles south of the riverport of Memphis, Tennessee. It was a center of cotton planter culture in the 19th century. The population was 15,205 at the 2010 census. It is the principal city of the Greenwood Micropolitan Statistical Area. Greenwood developed at the confluence of the Tallahatchie and the Yalobusha rivers, which form the Yazoo River. Throughout the 1960s, Greenwood was the site of major protests and conflicts as African Americans worked to achieve racial integration, voter registration and access during the civil rights movement.

Yazoo County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 28,065. The county seat is Yazoo City. It is named for the Yazoo River, which forms its western border. Its name is said to come from a Choctaw language word meaning "River of Death."

Coahoma County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 26,151. Its county seat is Clarksdale.The Clarksdale, MS Micropolitan Statistical Area includes all of Coahoma County. It is located in the Mississippi Delta region of Mississippi.