DeSoto County is a county located on the northwest border of the U.S. state of Mississippi. As of the 2010 census, the population was 161,252, making it the third-most populous county in Mississippi. Its county seat is Hernando.DeSoto County is part of the Memphis, TN-MS-AR Metropolitan Statistical Area. It is the second-most populous county in the MSA. The county has lowland areas that were developed in the 19th century for cotton plantations, and hill country in the eastern part of the county.

West Memphis is the largest city in Crittenden County, Arkansas, United States. The population was 26,245 at the 2010 census, ranking it as the state's 18th largest city, behind Bella Vista. It is part of the Memphis metropolitan area, and is located directly across the Mississippi River from Memphis, Tennessee.

Clarksdale is a city in and the county seat of Coahoma County, Mississippi, United States. It is located along the Sunflower River. Clarksdale is named after John Clark, a settler who founded the city in the mid-19th century when he established a timber mill and business. The western boundary of the county is formed by the Mississippi River. In the Mississippi Delta region, Clarksdale is an agricultural and trading center. Many African-American musicians developed the blues here, and took this original American music with them to Chicago and other northern cities during the Great Migration.

Coahoma County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 26,151. Its county seat is Clarksdale.The Clarksdale, MS Micropolitan Statistical Area includes all of Coahoma County. It is located in the Mississippi Delta region of Mississippi.