Huron is a city in Beadle County, South Dakota, United States. It is the county seat of Beadle County. The Huron Daily Plainsman, also referred to as the Plainsman, is the newspaper. The first settlement at Huron was made in 1880. The city was named after the Huron Indians. It is currently the seventh largest city in South Dakota, but it once was the fourth. In recent years, Huron's population has once again started to grow after nearly 20 years of stagnation. A welcoming immigration policy coupled with an economic revival in the area has sparked development. A Walmart Supercenter opened in the mid 2000s. Since Walmart's opening more commercial and residential development has occurred with the completion of a new Runnings store (retailer specializing in farm and fleet products), and many new apartments, twin homes and houses. The greater Huron area is home to approximately 30,000 people. The population within the city limits was 14,280 according to the 2020 census. Huron was once in the running for capital of South Dakota but lost out to Pierre due to Pierre's positioning. Huron is home to the South Dakota State Fair, which is held six days before Labor Day. It is also home to a statue known as "The World's Largest Pheasant", which was refurbished in the summer of 2011. Huron has rail service, provided by the Rapid City, Pierre and Eastern Railroad.

Chamberlain (Lakota: makȟáthipi; "earth dwelling") is a city in Brule County, South Dakota, United States. It is located on the eastern bank of the Missouri River, at the dammed section of the Lake Francis Case, close to where it is crossed by Interstate 90. The population of Chamberlain was 2,387 at the 2010 census. It is the county seat of Brule County.Chamberlain is home to the South Dakota Hall of Fame. It is the site of St. Joseph's Indian School, a Native American residential school established in 1927 and operated by the Catholic order Priests of the Sacred Heart. A 50-foot (15 m) sculpture of a Native American woman, entitled Dignity, was installed on a bluff overlooking the Missouri River outside the city.

Sioux Falls (; Lakota: Íŋyaŋ Okábleča Otȟúŋwahe; "Stone Shatter City") is the most populous city in the U.S. state of South Dakota and the 131st-most populous city in the United States. It is the county seat of Minnehaha County and also extends into Lincoln County to the south, proximate with the Iowa state line. As of 2020, Sioux Falls had a population of 192,517. The Sioux Falls metro area accounts for more than 30% of the state's entire population. Chartered in 1856 on the banks of the Big Sioux River, the city is situated in the rolling hills at the junction of interstates 29 and 90. According to Best Life magazine, Sioux Falls is the healthiest city in the United States and is often considered one of the healthiest cities in the US by many other organizations.

Yankton is a city in and the county seat of Yankton County, South Dakota, United States. Yankton had a population of 14,454 at the 2010 census and it is the principal city of the Yankton Micropolitan Statistical Area, which includes the entirety of Yankton County and which had an estimated population of 22,662 as of July 1, 2017. Yankton was the first capital of Dakota Territory. It is named for the Yankton tribe of Western Dakota people; Yankton is derived from the Dakota word I-hank-ton-wan ("the end village").Yankton is located on the Missouri River just downstream of the Gavins Point Dam and Lewis and Clark Lake, and just upstream of the confluence with the James River. The United States National Park Service's headquarters for the Missouri National Recreational River are located in the city. The Human Services Center was established as a psychiatric hospital in 1882 and is on the National Register of Historic Places. Yankton is commonly referred to as the "River City", due to its proximity to the Missouri River and the importance the river played in the city's settlement and development. Yankton has also earned the nickname "Mother City of the Dakotas", due to the early important role it played in the creation and development of the Dakota Territory, which later became the 39th and 40th U.S. states of North and South Dakota.Owing to the early exploitation of Fort Hays Limestone for cement manufacture, including shipment of cement to the construction of the Panama Canal, Yankton once also had the nickname "Cement City".