Alpine ( AL-pyne) is a city in and the county seat of Brewster County, Texas, United States. The population was 5,905 at the 2010 census. The town has an elevation of 4,475 feet (1,364 m), and the surrounding mountain peaks are over 1 mile (1.6 km) above sea level. The university, hospital, library, and retail make Alpine the center of the sprawling 12,000 square miles (3,108,000 ha) but wide open Big Bend area (combined population only 12,500) including Brewster, Presidio, and Jeff Davis counties.

Marfa is a city in the high desert of the Trans-Pecos in far West Texas, between the Davis Mountains and Big Bend National Park. It is the county seat of Presidio County, and its population as of the 2010 United States Census was 1,981. The city was founded in the early 1880s as a water stop; the population increased during World War II, but growth has stalled and reversed somewhat since the late 20th century. Today, Marfa is a tourist destination and a major center for minimalist art. Attractions include Building 98, the Chinati Foundation, artisan shops, historical architecture, a classic Texas town square, modern art installments, art galleries, and the Marfa lights.

Pecos ( PAY-kəs) is the largest city in and the county seat of Reeves County, Texas, United States. It is in the valley on the west bank of the Pecos River at the eastern edge of the Chihuahuan Desert, in the Trans-Pecos region of West Texas and just south of New Mexico's border. Its population was 8,780 at the 2010 census. On January 24, 2012, Pecos City appeared on the Forbes 400 as the second-fastest growing small town in the United States. The city is a regional commercial center for ranching, oil and gas production, and agriculture. The city is most recognized for its association with the local cultivation of cantaloupes. Pecos claims to be the site of the world's first rodeo on July 4, 1883.

Odessa is a city in and the county seat of Ector County, Texas, United States. It is located primarily in Ector County, although a small section of the city extends into Midland County. Odessa's population was 114,428 at the 2020 census, making it the 28th-most populous city in Texas;It is the principal city of the Odessa metropolitan statistical area, which includes all of Ector County. The metropolitan area is also a component of the larger Midland–Odessa combined statistical area, which had a 2010 census population of 278,801; a recent report from the United States Census Bureau estimates that the combined population as of July 2015 is 320,513. In 2014, Forbes magazine ranked Odessa as the third-fastest-growing small city in the United States. In 1948 Odessa was also the home of First Lady Barbara Bush, and the onetime home of former Presidents George H. W. Bush and George W. Bush. Former President George H.W. Bush has been quoted as saying "At Odessa we became Texans and proud of it."