Big Spring is a city in and the county seat of Howard County, Texas, United States, at the crossroads of U.S. Highway 87 and Interstate 20. With a population of 27,282 as of the 2010 census, it is the largest city between Midland to the west, Abilene to the east, Lubbock to the north, and San Angelo to the south. Big Spring was established as the county seat of Howard County in 1882; it is the largest community in the county. The city took its name from the single, large spring that issued into a small gorge between the base of Scenic Mountain and a neighboring hill in the southwestern part of the city limits. Although the name is sometimes still mistakenly pluralized, it is officially singular. "To the native or established residents who may wince at the plural in Big Spring, it should be explained that until about 1916, when for some unexplained reason the name dropped the final 's', the official name of the town was indeed Big Springs."

Midland is a city in and the county seat of Midland County, Texas, United States, on western Texas's Southern Plains. A small part of Midland is in Martin County. At the 2010 census, Midland's population was 111,147, and a 2019 estimate put it at 176,832, making it Texas's 24th-most populous city. It is the principal city of the Midland, Texas metropolitan statistical area, which includes all of Midland County, the population of which grew 4.6% between July 1, 2011, and July 1, 2012, to 151,662, according to the U.S. Census Bureau. The metropolitan area is part of the larger Midland–Odessa combined statistical area, which had an estimated population of 295,987 on July 1, 2012. People in Midland are called Midlanders. Midland was founded as the midway point between Fort Worth and El Paso on the Texas and Pacific Railroad in 1881. It is the hometown of former First Lady Laura Bush, and the onetime home of former Presidents George H. W. Bush and George W. Bush, and former First Lady Barbara Bush.

Sweetwater is a municipality in and the seat of Nolan County, Texas, United States. It is 236 miles southeast of Amarillo and 181 miles west of Fort Worth. Its population was 10,906 at the 2010 census.

Amarillo ( AM-ə-RIL-oh; Spanish for "yellow") is a city in the U.S. state of Texas and the seat of Potter County. It is the 14th-most populous city in Texas and the largest city in the Texas Panhandle. A portion of the city extends into Randall County. The estimated population of Amarillo was 199,371 as of 2019. The Amarillo metropolitan area had an estimated population of 269,447 as of 2019, and the Amarillo-Pampa-Borger combined statistical area a population of 308,064.The city of Amarillo, originally named Oneida, is situated in the Llano Estacado region. The availability of the railroad and freight service provided by the Fort Worth and Denver City Railroad contributed to the city's growth as a cattle-marketing center in the late 19th century.Amarillo was once the self-proclaimed "Helium Capital of the World" for having one of the country's most productive helium fields. The city is also known as "The Yellow Rose of Texas" (as the city takes its name from the Spanish word for yellow), and most recently "Rotor City, USA" for its V-22 Osprey hybrid aircraft assembly plant. Amarillo operates one of the largest meat-packing areas in the United States. Pantex, the only nuclear weapons assembly and disassembly facility in the country, is also a major employer. The location of this facility also gave rise to the nickname "Bomb City". The attractions Cadillac Ranch and Big Texan Steak Ranch are located adjacent to Interstate 40. U.S. Highway 66 also passed through the city.