Odessa is a city in and the county seat of Ector County, Texas, United States. It is located primarily in Ector County, although a small section of the city extends into Midland County. Odessa's population was 114,428 at the 2020 census, making it the 28th-most populous city in Texas;It is the principal city of the Odessa metropolitan statistical area, which includes all of Ector County. The metropolitan area is also a component of the larger Midland–Odessa combined statistical area, which had a 2010 census population of 278,801; a recent report from the United States Census Bureau estimates that the combined population as of July 2015 is 320,513. In 2014, Forbes magazine ranked Odessa as the third-fastest-growing small city in the United States. In 1948 Odessa was also the home of First Lady Barbara Bush, and the onetime home of former Presidents George H. W. Bush and George W. Bush. Former President George H.W. Bush has been quoted as saying "At Odessa we became Texans and proud of it."

Big Spring is a city in and the county seat of Howard County, Texas, United States, at the crossroads of U.S. Highway 87 and Interstate 20. With a population of 27,282 as of the 2010 census, it is the largest city between Midland to the west, Abilene to the east, Lubbock to the north, and San Angelo to the south. Big Spring was established as the county seat of Howard County in 1882; it is the largest community in the county. The city took its name from the single, large spring that issued into a small gorge between the base of Scenic Mountain and a neighboring hill in the southwestern part of the city limits. Although the name is sometimes still mistakenly pluralized, it is officially singular. "To the native or established residents who may wince at the plural in Big Spring, it should be explained that until about 1916, when for some unexplained reason the name dropped the final 's', the official name of the town was indeed Big Springs."

Pecos ( PAY-kəs) is the largest city in and the county seat of Reeves County, Texas, United States. It is in the valley on the west bank of the Pecos River at the eastern edge of the Chihuahuan Desert, in the Trans-Pecos region of West Texas and just south of New Mexico's border. Its population was 8,780 at the 2010 census. On January 24, 2012, Pecos City appeared on the Forbes 400 as the second-fastest growing small town in the United States. The city is a regional commercial center for ranching, oil and gas production, and agriculture. The city is most recognized for its association with the local cultivation of cantaloupes. Pecos claims to be the site of the world's first rodeo on July 4, 1883.

Sweetwater is a municipality in and the seat of Nolan County, Texas, United States. It is 236 miles southeast of Amarillo and 181 miles west of Fort Worth. Its population was 10,906 at the 2010 census.